Cell Therapy 3.0

Built on Signal 3

Traversing uncharted signal landscapes with synthetic cytokine receptors to engineer any cell into a cure.

Challenge

Cytokines are the master regulators of cellular function, the universal language that instructs cells to persist, differentiate, fight, and beyond. Through receptor binding, they deliver Signal 3, the programming that separates durable cures from fleeting responses. Yet this critical layer remains effectively inaccessible, limiting the full potential of cell therapy.
We need better tools. Current protein designs for cytokines are either highly toxic or functionally inert. Modern synthetic receptors are biophysically incompatible with authentic Signal 3.
We need functional maps. Screens to identify cytokines that optimize therapeutic function are intractable, so a handful of legacy cytokines dominate the field out of familiarity, not superiority. Worse, cells naturally access only ~10% of the Signal 3 landscape, leaving most of its instructive power untapped

Platform

Enoda solved a core protein engineering challenge, creating a receptor architecture that links any Signal 3 to clinically relevant inputs, free from the constraints of cytokines.

Our MIMIC assets enable cell therapies to harness functional Signal 3s without systemic toxicity - expanding what engineered cells are capable of.

MIMICs: Synthetic Cytokine Receptors

First High-Throughput Signal 3 Screens

Enoda built a MIMIC library linking every natural Signal 3 - and even entirely new synthetic ones - to a shared input.

With it, we tractably map the entire Signal 3 landscape, unlocking therapeutic programs cells cannot naturally access and freeing cell therapy from the limits of what is currently known.